TY  - JOUR
A1  - Farré-Colomés, Àlvar
A1  - Gerhardt, Sarah
A1  - Luderer, Mathias
A1  - Sobanski, Esther
A1  - Kiefer, Falk
A1  - Vollstädt-Klein, Sabine
T1  - Common and distinct neural connectivity in attention-deficit/hyperactivity disorder and alcohol use disorder studied using resting-state functional magnetic resonance imaging
T2  - Alcoholism : clinical and experimental research
N2  - Background: A link between attention-deficit/hyperactivity disorder (ADHD) and alcohol use disorder (AUD) has been widely demonstrated. In this study, we used neuroimaging to investigate the connectivity traits that may contribute to the comorbidity of these disorders.
Methods: The study included an AUD group (N = 18), an ADHD group (N = 17), a group with AUD + ADHD comorbidity (N = 12) and a control group (N = 18). We used resting-state functional connectivity in a seed-based approach in the default mode networks, the dorsal attention network, and the salience network.
Results: Within the default mode networks, all affected groups shared greater connectivity toward the temporal gyrus when compared to the control group. Regarding the dorsal attention network, the Brodmann area 6 presented greater connectivity for each affected group in comparison with the control group, displaying the strongest aberrations in the AUD + ADHD group. In the salience network, the prefrontal cortex showed decreased connectivity in each affected group compared to the control group.
Conclusions: Despite the small and unequal sample sizes, our findings show evidence of common neurobiological alterations in AUD and ADHD, supporting the hypothesis that ADHD could be a risk factor for the development of AUD. The results highlight the importance of an early ADHD diagnosis and treatment to reduce the risk of a subsequent AUD.
KW  - alcohol use disorder
KW  - default mode network
KW  - dorsal attention network
KW  - salience network
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61831
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-618318
SN  - 1530-0277
VL  - 45
IS  - 5
SP  - 948
EP  - 960
PB  - Wiley-Blackwell
CY  - Oxford
ER  -