TY  - JOUR
A1  - Moreno-Oyervides, Aldo
A1  - Aguilera-Morillo, M. Carmen
A1  - Cruz Fernández, María José de la
A1  - Lecumberri Pascual, Edurne
A1  - Llanos Jiménez, Lucía
A1  - Krozer, Viktor
A1  - Acedo, Pablo
T1  - Clinical assessment of W-band spectroscopy for non-invasive detection and monitoring of sustained hyperglycemia
T2  - Biomedical optics express
N2  - HbA1c is the gold standard test for monitoring medium/long term glycemia conditions in diabetes care, which is a critical factor in reducing the risk of chronic diabetes complications. Current technologies for measuring HbA1c concentration are invasive and adequate assays are still limited to laboratory-based methods that are not widely available worldwide. The development of a non-invasive diagnostic tool for HbA1c concentration can lead to the decrease of the rate of undiagnosed cases and facilitate early detection in diabetes care. We present a preliminary validation diagnostic study of W-band spectroscopy for detection and monitoring of sustained hyperglycemia, using the HbA1c concentration as reference. A group of 20 patients with type 1 diabetes mellitus and 10 healthy subjects were non-invasively assessed at three different visits over a period of 7 months by a millimeter-wave spectrometer (transmission mode) operating across the full W-band. The relationship between the W-band spectral profile and the HbA1c concentration is studied using longitudinal and non-longitudinal functional data analysis methods. A potential blind discrimination between patients with or without diabetes is obtained, and more importantly, an excellent relation (R-squared = 0.97) between the non-invasive assessment and the HbA1c measure is achieved. Such results support that W-band spectroscopy has great potential for developing a non-invasive diagnostic tool for in-vivo HbA1c concentration monitoring in humans.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63085
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-630853
SN  - 2156-7085
N1  - Instituto de Salud Carlos III (DTS17/00135). Aldo Moreno-Oyervides thanks the Consejo Nacional de Ciencia y Tecnología de México (CONACYT) for financially supporting his doctoral education (PhD. Grant) associated to this work. This work has been supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M26), and in the context of the V PRICIT (Regional Programme of Research and Technological Innovation).
VL  - 12.2021
IS  - 8
SP  - 5008
EP  - 5022
PB  - Optica
CY  - Washington, DC
ER  -