TY  - JOUR
A1  - Abele, Rupert
A1  - Tampé, Robert
T1  - Moving the cellular peptidome by transporters
T2  - Frontiers in cell developmental biology
N2  - Living matter is defined by metastability, implying a tightly balanced synthesis and turnover of cellular components. The first step of eukaryotic protein degradation via the ubiquitin-proteasome system (UPS) leads to peptides, which are subsequently degraded to single amino acids by an armada of proteases. A small fraction of peptides, however, escapes further cytosolic destruction and is transported by ATP-binding cassette (ABC) transporters into the endoplasmic reticulum (ER) and lysosomes. The ER-resident heterodimeric transporter associated with antigen processing (TAP) is a crucial component in adaptive immunity for the transport and loading of peptides onto major histocompatibility complex class I (MHC I) molecules. Although the function of the lysosomal resident homodimeric TAPL-like (TAPL) remains, until today, only loosely defined, an involvement in immune defense is anticipated since it is highly expressed in dendritic cells and macrophages. Here, we compare the gene organization and the function of single domains of both peptide transporters. We highlight the structural organization, the modes of substrate binding and translocation as well as physiological functions of both organellar transporters.
KW  - ABC transporter
KW  - antigen processing
KW  - antigen presentation
KW  - membrane proteins
KW  - viral immune escape
KW  - lysosome
KW  - endoplasmic reticulum
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51469
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-514693
N1  - Copyright © 2018 Abele and Tampé. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/ . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 6
IS  - Article 43
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -