TY  - INPR
A1  - Mühlroth, Beate Elisabeth
A1  - Sander, Myriam Christine
A1  - Fandakova, Yana
A1  - Grandy, Thomas H.
A1  - Rasch, Björn
A1  - Shing, Yee Lee
A1  - Werkle-Bergner, Markus
T1  - Memory quality modulates the effect of aging on memory consolidation during sleep: reduced maintenance but intact gain
T2  - bioRxiv
N2  - Successful consolidation of associative memories relies on the coordinated interplay of slow oscillations and sleep spindles during non-rapid eye movement (NREM) sleep, enabling the transfer of labile information from the hippocampus to permanent memory stores in the neocortex. During senescence, the decline of the structural and functional integrity of the hippocampus and neocortical regions is paralleled by changes of the physiological events that stabilize and enhance associative memories during NREM sleep. However, the currently available evidence is inconclusive if and under which circumstances aging impacts memory consolidation. By tracing the encoding quality of single memories in individual participants, we demonstrate that previous learning determines the extent of age-related impairments in memory consolidation. Specifically, the detrimental effects of aging on memory maintenance were greatest for mnemonic contents of medium encoding quality, whereas memory gain of weakly encoded memories did not differ by age. Using multivariate techniques, we identified profiles of alterations in sleep physiology and brain structure characteristic for increasing age. Importantly, while both ‘aged’ sleep and ‘aged’ brain structure profiles were associated with reduced memory maintenance, inter-individual differences in neither sleep nor structural brain integrity qualified as the driving force behind age differences in sleep-dependent consolidation in the present study.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72532
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-725328
IS  - 547448
ER  -