TY  - JOUR
A1  - Keller, Till
A1  - Boeckel, Jes-Niels
A1  - Groß, Stefan
A1  - Klotsche, Jens
A1  - Palapies, Lars
A1  - Leistner, David
A1  - Pieper, Lars
A1  - Stalla, Günnter K.
A1  - Lehnert, Hendrik
A1  - Silber, Sigmund
A1  - Pittrow, David
A1  - März, Winfried
A1  - Dörr, Marcus
A1  - Wittchen, Hans-Ulrich
A1  - Baumeister, Sebastian E.
A1  - Völker, Uwe
A1  - Felix, Stephan B.
A1  - Dimmeler, Stefanie
A1  - Zeiher, Andreas M.
T1  - Improved risk stratification in prevention by use of a panel of selected circulating microRNAs
T2  - Scientific reports
N2  - Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 and miR-133 were determined from peripheral blood by qPCR and combined to a risk panel. As derivation cohort, 178 individuals of the DETECT study, and as validation cohort, 129 individuals of the SHIP study were used in a case-control approach. Overall mortality and cardiovascular events were outcome measures. The Framingham Risk Score(FRS) and the SCORE system were applied as risk classification systems. The identified miR panel was significantly associated with mortality given by a hazard ratio(HR) of 3.0 (95% (CI): 1.09–8.43; p = 0.034) and of 2.9 (95% CI: 1.32–6.33; p = 0.008) after adjusting for the FRS in the derivation cohort. In a validation cohort the miR-panel had a HR of 1.31 (95% CI: 1.03–1.66; p = 0.03) and of 1.29 (95% CI: 1.02–1.64; p = 0.03) in a FRS/SCORE adjusted-model. A FRS/SCORE risk model was significantly improved to predict mortality by the miR panel with continuous net reclassification index of 0.42/0.49 (p = 0.014/0.005). The present miR panel of 5 circulating miRs is able to improve risk stratification in prevention with respect to mortality beyond the FRS or SCORE.
KW  - miRNAs
KW  - Prognostic markers
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48607
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-486075
SN  - 2045-2322
N1  - Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
VL  - 7
IS  - 1, Art. 4511
SP  - 1
EP  - 9
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -