TY  - JOUR
A1  - Kempf, Kerstin
A1  - Röhling, Martin
A1  - Banzer, Winfried
A1  - Braumann, Klaus-Michael
A1  - Halle, Martin
A1  - Schaller, Nina
A1  - McCarthy, David
A1  - Predel, Hans Georg
A1  - Schenkenberger, Isabelle
A1  - Tan, Susanne
A1  - Toplak, Hermann
A1  - Martin, Stephan
A1  - Berg, Aloys
T1  - Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement - a subanalysis of the randomised-controlled ACOORH Trial
T2  - Nutrients
N2  - Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria (n = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data (n = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline (p < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference −3.4 µg/L [1.4; 5.4] for females; −2.2 µg/L [1.2; 3.3] for males; p < 0.001 each) and was predictive for stronger reduction of body weight and fat mass (p < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (−5.9 ± 5.1 kg in females of the intervention group vs. −2.9 ± 4.9 kg in the control group (p < 0.0001); −6.8 ± 5.3 kg vs. −4.1 ± 4.4 kg (p = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss.
KW  - leptin
KW  - protein-rich
KW  - low-glycaemic meal replacement
KW  - weight reduction
KW  - multicentre study
KW  - RCT
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72093
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-720933
SN  - 2072-6643
N1  - This research was funded by Almased-Wellness-GmbH.
N1  - The datasets generated during and/or analysed during the current study are not publicly available but are available from the corresponding author on reasonable request.
VL  - 14
IS  - 12, art.  2537
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  -