TY  - JOUR
A1  - Lehrnbecher, Thomas
A1  - Schmidt, Stanislaw
A1  - Tramsen, Lars
A1  - Klingebiel, Thomas
T1  - Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients
T2  - Frontiers in oncology
N2  - Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients suffer from a long lasting defect of different arms of the immune system, which increases the risk for and deteriorates the prognosis of invasive fungal infections. In turn, advances in understanding these immune deficits have resulted in promising strategies to enhance or restore critical immune functions in allogeneic HSCT recipients. Potential approaches include the administration of granulocytes, since neutropenia is the single most important risk factor for invasive fungal infection, and preliminary clinical results suggest a benefit of adoptively transferred donor-derived antifungal T cells. In vitro data and animal studies demonstrate an antifungal effect of natural killer cells, but clinical data are lacking to date. This review summarizes and critically discusses the available data of immunotherapeutic strategies in allogeneic HSCT recipients suffering from invasive fungal infection.
KW  - invasive fungal infection
KW  - allogeneic hematopoietic stem cell transplantation
KW  - immunotherapy
KW  - T cell
KW  - natural killer cell
KW  - granulocyte
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28892
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-288925
SN  - 2234-943X
N1  - Copyright: © 2013 Lehrnbecher, Schmidt, Tramsen and Klingebiel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
VL  - 3
IS  - Article 17
PB  - Frontiers Media
CY  - Lausanne
ER  -