TY  - JOUR
A1  - Dimmeler, Stefanie
A1  - Nicotera, Pierluigi
T1  - MicroRNAs in age-related diseases
T2  - EMBO molecular medicine
N2  - Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, aging and disease. However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.
KW  - cardiac
KW  - microRNA
KW  - neurodegeneration
KW  - senescence
KW  - vascular
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28789
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-287890
SN  - 1715-4684
SN  - 1757-4676
N1  - Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO. This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
VL  - 5
IS  - 2
SP  - 180
EP  - 190
PB  - Wiley-VCH
CY  - Weinheim
ER  -