TY  - JOUR
A1  - Eberhardt, Wolfgang
A1  - Häußler, Kristina
A1  - Nasrullah, Usman
A1  - Pfeilschifter, Josef
T1  - Multifaceted roles of TRIM proteins in colorectal carcinoma
T2  - International journal of molecular sciences
N2  - Colorectal cancer (CRC) is one of the most frequently diagnosed tumor in humans and one of the most common causes of cancer-related death worldwide. The pathogenesis of CRC follows a multistage process which together with somatic gene mutations is mainly attributed to the dysregulation of signaling pathways critically involved in the maintenance of homeostasis of epithelial integrity in the intestine. A growing number of studies has highlighted the critical impact of members of the tripartite motif (TRIM) protein family on most types of human malignancies including CRC. In accordance, abundant expression of many TRIM proteins has been observed in CRC tissues and is frequently correlating with poor survival of patients. Notably, some TRIM members can act as tumor suppressors depending on the context and the type of cancer which has been assessed. Mechanistically, most cancer-related TRIMs have a critical impact on cell cycle control, apoptosis, epithelial–mesenchymal transition (EMT), metastasis, and inflammation mainly through directly interfering with diverse oncogenic signaling pathways. In addition, some recent publications have emphasized the emerging role of some TRIM members to act as transcription factors and RNA-stabilizing factors thus adding a further level of complexity to the pleiotropic biological activities of TRIM proteins. The current review focuses on oncogenic signaling processes targeted by different TRIMs and their particular role in the development of CRC. A better understanding of the crosstalk of TRIMs with these signaling pathways relevant for CRC development is an important prerequisite for the validation of TRIM proteins as novel biomarkers and as potential targets of future therapies for CRC.
KW  - apoptosis
KW  - colorectal cancer (CRC)
KW  - epithelial-to-mesenchymal transition (EMT)
KW  - TRIMs
KW  - oncogenic signaling
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56416
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-564163
SN  - 1422-0067
SN  - 1661-6596
N1  - © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
VL  - 21
IS  - art. 7532
SP  - 1
EP  - 29
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -