TY  - JOUR
A1  - Călinescu, Octavian
A1  - Danner, Eva
A1  - Böhm, Marc
A1  - Hunte, Carola
A1  - Fendler, Klaus
T1  - Species differences in bacterial NhaA Na+/H+ exchangers
T2  - FEBS letters
N2  - Bacteria have adapted their NhaA Na(+)/H(+) exchangers responsible for salt homeostasis to their different habitats. We present an electrophysiological and kinetic analysis of NhaA from Helicobacter pylori and compare it to the previously investigated exchangers from Escherichia coli and Salmonella typhimurium. Properties of all three transporters are described by a simple model using a single binding site for H(+) and Na(+). We show that H.pylori NhaA only has a small acidic shift of its pH-dependent activity profile compared to the other transporters and discuss why a more drastic change in its pH activity profile is not physiologically required.
KW  - NhaA
KW  - Cation/proton antiport
KW  - Solid supported membrane
KW  - Helicobacter pylori
KW  - Escherichia coli
KW  - Salmonella typhimurium
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34576
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-345764
SN  - 1873-3468
SN  - 0014-5793
N1  - (c) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
VL  - 558
IS  - 17
SP  - 3111
EP  - 3116
PB  - Elsevier
CY  - Amsterdam [u. a.]
ER  -