TY  - JOUR
A1  - Zöllner, Johann Philipp
A1  - Misselwitz, Björn
A1  - Mauroschat, Thomas
A1  - Roth, Christian
A1  - Steinmetz, Helmuth
A1  - Rosenow, Felix
A1  - Strzelczyk, Adam
T1  - Intravenous thrombolysis or mechanical thrombectomy do not increase risk of acute symptomatic seizures in patients with ischemic stroke
T2  - Scientific reports
N2  - Recent data have suggested that performing recanalizing therapies in ischemic stroke might lead to an increased risk of acute symptomatic seizures. This applies to both intravenous thrombolysis and mechanical thrombectomy. We therefore determined the frequency of acute symptomatic seizures attributable to these two recanalization therapies using a large, population-based stroke registry in Central Europe. We performed two matched 1:1 case–control analyses. In both analyses, patients were matched for age, stroke severity on admission and pre-stroke functional status. The first analysis compared patients treated with intravenous thrombolysis to a non-recanalization control group. To isolate the effect of mechanical thrombectomy, we compared patients with both mechanical thrombectomy and intravenous thrombolysis to those with only intravenous thrombolysis treatment in a second analysis. From 135,117 patients in the database, 13,356 patients treated with only intravenous thrombolysis, and 1013 patients treated with both intravenous thrombolysis and mechanical thrombectomy were each matched to an equivalent number of controls. Patients with intravenous thrombolysis did not suffer from clinically apparent acute symptomatic seizures significantly more often than non-recanalized patients (treatment = 199; 1.5% vs. control = 237; 1.8%, p = 0.07). Mechanical thrombectomy in addition to intravenous thrombolysis also was not associated with an increased risk of acute symptomatic seizures, as the same number of patients suffered from seizures in the treatment and control group (both n = 17; 1.7%, p = 1). In a large population-based stroke registry, the frequency of clinically apparent acute symptomatic seizures was not increased in patients who received either intravenous thrombolysis alone or in conjunction with mechanical thrombectomy.
KW  - Cerebrovascular disorders
KW  - Epilepsy
KW  - Stroke
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75691
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-756915
SN  - 2045-2322
N1  - Open Access funding enabled and organized by Projekt DEAL. This study was supported by a LOEWE Grant from the State of Hessen to F.R. and A.S. (Teilprojekte 1/4) for the “Center for Personalized Translational Epilepsy Research” (CePTER), Goethe University Frankfurt, Frankfurt am Main, Germany.
N1  - Data are available upon request by qualified researchers from the Geschäftsstelle Qualitätssicherung Hessen (GQH), pending certain prerequisites.
N1  - All code used is available as part of SPSS, version 26 (IBM Corp., Armonk, NY, USA).
VL  - 10
IS  - art. 21083
SP  - 1
EP  - 7
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -