TY  - JOUR
A1  - Lehrnbecher, Thomas
A1  - Aplenc, Richard
A1  - Pereira, Fernanda Rivas
A1  - Lassaletta, Alvaro
A1  - Caselli, Désirée
A1  - Kowalczyk, Jerzy
A1  - Chisholm, Julia
A1  - Sung, Lillian
T1  - Variations in non-pharmacological anti-infective measures in childhood leukemia - results of an international survey
T2  - Haematologica
N2  - Background: Standardization in clinical practice may lead to improved outcomes. Unfortunately, little is known about the variability of non-pharmacological anti-infective measures in children with cancer.
Design and Methods: A web-based survey assessed institutional recommendations regarding restrictions of social contacts, pets and food and instructions on wearing face masks in public for children with standard- risk acute lymphoblastic leuk emia and acute myeloid leukemia during intensive chemotherapy.
Results: A total of 336 institutions in 27 countries responded to the survey (range, 1-76 institutions per country; overall response rate 61%). Most institutions recommend that patients with acute myeloid leukemia avoid indoor public places and daycare, kindergarten and school, whereas recommendations for patients with acute lymphoblastic leukemia differ considerably by institution. In terms of restrictions related to pets, there was a wide variability between institutions for both acute lymphoblastic and acute myeloid leukemia patients. Most, but not all institutions do not allow children with either acute lymphoblastic or acute myeloid leukemia to eat raw meat, raw seafood or unpasteurized milk. Whereas most institutions do not routinely recommend that patients with acute lymphoblastic leukemia wear face masks in public, advice on this matter varies for patients with acute myeloid leukemia.
Conclusions: The survey demonstrates that there is a wide variation in recommendations on non-pharmacological anti-infective measures between different institutions, countries and continents. This information may be used to encourage harmonization of supportive care practices and future clinical trials.
KW  - acute lymphoblastic leukemia
KW  - acute myeloid leukemia
KW  - child
KW  - infection
KW  - non - pharmacological anti-infective measures
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43923
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-439234
VL  - 97
IS  - 10
SP  - 1548
EP  - 1552
PB  - European Hematology Association
ER  -