TY  - JOUR
A1  - Lehrnbecher, Thomas
A1  - Hassler, Angela
A1  - Groll, Andreas Hermann
A1  - Bochennek, Konrad
T1  - Diagnostic approaches for invasive aspergillosis—specific considerations in the pediatric population
T2  - Frontiers in microbiology
N2  - Invasive aspergillosis (IA) is a major cause of morbidity and mortality in children with hematological malignancies and those undergoing hematopoietic stem cell transplantation. Similar to immunocompromised adults, clinical signs, and symptoms of IA are unspecific in the pediatric patient population. As early diagnosis and prompt treatment of IA is associated with better outcome, imaging and non-invasive antigen-based such as galactomannan or ß-D-glucan and molecular biomarkers in peripheral blood may facilitate institution and choice of antifungal compounds and guide duration of therapy. In patients in whom imaging studies suggest IA or another mold infection, invasive diagnostics such as bronchoalveolar lavage and/or bioptic procedures should be considered. Here we review the current data of diagnostic approaches for IA in the pediatric setting and highlight the major differences of performance and clinical utility of the tests between children and adults.
KW  - Aspergillus
KW  - child
KW  - cancer
KW  - diagnostics
KW  - galactomannan
KW  - ß-D-glucan
KW  - polymerase chain reaction
KW  - imaging
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46300
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-463007
SN  - 1664-302X
N1  - Copyright: © 2018 Lehrnbecher, Hassler, Groll and Bochennek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 9
IS  - Art. 518
SP  - 1
EP  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  -