TY  - JOUR
A1  - Koç-Günel, Sinem
A1  - Tekeli, Nesrin
A1  - Smaczny, Christina
A1  - Vogl, Thomas J.
A1  - Rohde, Gernot Gerhard Ulrich
T1  - A case of Lymphangioleiomyomatosis (LAM) of the lung in a patient with a history of breast cancer
T2  - The American journal of case reports
N2  - Background: Lymphangioleiomyomatosis (LAM) is a rare progressive cystic and nodular disease of the lung characterized by smooth muscle cell proliferation. LAM predominantly affects young premenopausal women. This report is of a case of LAM presenting in a 47-year-old woman with a past history of breast cancer and discusses the possibility of an association between the two conditions.
Case report: A 47-year-old woman presented as an emergency with an exacerbation of a four-month history of shortness of breath and dry cough. Her symptoms began following the start of anti-hormonal treatment with letrozole and goserelin acetate for a moderately differentiated (grade 2) invasive ductal carcinoma of the breast (pT2, pN0, M0) which was positive for expression of estrogen receptor (ER+), progesterone receptor (PR+), and human epidermal growth factor receptor 2 (HER2+). Until the previous four months, she had breast-conserving treatment with radiotherapy and tamoxifen therapy. Following hospital admission, she was found to be in type I respiratory failure. Chest X-ray, lung computed tomography (CT), and positron-emission tomography (PET) showed diffuse cystic and nodular lung lesions, consistent with a diagnosis of LAM, and antihormonal therapy was discontinued. She developed pericarditis that was treated with the anti-inflammatory agent, colchicine. Treatment with letrozole and sirolimus improved her respiratory symptoms.
Conclusions: A rare case of LAM is presented in a woman with a recent history of breast cancer. Because both tumors were hormone-dependent, this may support common underlying gene associations and signaling pathways between the two types of tumor.
KW  - Aromatase Inhibitors
KW  - Carcinoma, Ductal, Breast
KW  - Colchicum
KW  - Estrogen Receptor Modulators
KW  - Goserelin
KW  - Lymphangioleiomyomatosis
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/49301
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-493017
SN  - 1941-5923
N1  - This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
VL  - 20
SP  - 390
EP  - 393
PB  - International Scientific Literature
CY  - New York, NY
ER  -