TY  - JOUR
A1  - Wagner, Julian Uwe Gabriel
A1  - Dimmeler, Stefanie
T1  - Cellular cross-talks in the diseased and aging heart
T2  - Journal of Molecular and Cellular Cardiology
N2  - Communication between cells is an important, evolutionarily conserved mechanism which enables the coordinated function of multicellular organisms. Heterogeneity within cell populations drive a remarkable network of cellular cross-talk that allows the heart to function as an integrated unit with distinct tasks allocated to sub-specialized cells. During diseases and aging, cells acquire an overt disordered state that significantly contributes to an altered cellular cross-talk and hence drive cardiac remodeling processes and cardiovascular diseases. However, adaptive mechanisms, and phenotypic changes in subpopulations of cells (e.g. reparative macrophages or fibroblasts) can also contribute to repair and regeneration. In this article, we review the cellular cross-talks between immune cells, endothelial cells, fibroblasts and cardiomyocytes that control heart failure by contributing to cardiac dysfunction and aging, or by mediating repair and regeneration of the heart after injury.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75931
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-759311
SN  - 0022-2828
VL  - 138.2020
SP  - 136
EP  - 146
PB  - Elsevier
CY  - Amsterdam
ER  -