TY  - JOUR
A1  - Pham, Tan Phát
A1  - Bink, Diewertje I.
A1  - Stanicek, Laura
A1  - Bergen, Anke van
A1  - Leeuwen, Esmee van
A1  - Tran, Yvonne
A1  - Matic, Ljubica
A1  - Hedin, Ulf
A1  - Wittig, Ilka
A1  - Dimmeler, Stefanie
A1  - Boon, Reinier
T1  - Long non-coding RNA aerrie controls DNA damage repair via YBX1 to maintain endothelial cell function
T2  - Frontiers in cell and developmental biology
N2  - Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase in DNA damage is one of the hallmarks of aging and can be repaired by the DNA signaling and repair system. In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. This study identifies Aerrie as a novel factor in genomic stability and as a binding partner of YBX1 in responding to DNA damage.
KW  - LncRNA - long noncoding RNA
KW  - Endothelial cell (EC)
KW  - Aging
KW  - DNA Damage
KW  - cardiovascular disease
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57546
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-575465
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.619079/abstract
SN  - 2296-634X
VL  - 8
IS  - Article 619079
PB  - Frontiers Media
CY  - Lausanne
ER  -