TY  - JOUR
A1  - Müller-von der Grün, Jens
A1  - Tahtali, Aykut
A1  - Ghanaati, Shahram Michael
A1  - Rödel, Claus
A1  - Balermpas, Panagiotis
T1  - Diagnostic and treatment modalities for patients with cervical lymph node metastases of unknown primary site - current status and challenges
T2  - Radiation oncology
N2  - Background and Purpose: This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown primary (CUP).
Methods: A literature search for head and neck CUP was performed with focus on diagnostics and therapies as well as molecular markers.
Results: High level evidence on CUP is limited. However, it seems that a consensus exists regarding the optimal diagnostic procedures. The correct implementation of biomarkers for patient stratification and treatment remains unclear. An even greater dispute dominates about the ideal treatment with publications ranging from sole surgery to surgery with postoperative bilateral radiotherapy with inclusion of the mucosa and concomitant chemotherapy.
Conclusions: Cervical CUP represents a very heterogeneous malignant disease. On this account many aspects concerning treatment optimization remain unclear, despite a considerable number of publications in the past. Future research in form of prospective randomized trials is needed in order to better define patient stratification criteria and enable tailored treatment.
KW  - CUP
KW  - Cancer of unknown primary
KW  - Cervical
KW  - Lymph node
KW  - Head and neck cancer
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44107
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-441076
SN  - 1748-717X
N1  - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
VL  - 12
IS  - 1, Art. 82
SP  - 1
EP  - 12
PB  - BioMed Central
CY  - London
ER  -