TY  - JOUR
A1  - Eickholz, Peter
A1  - Schröder, Mario Pascal
A1  - Asendorf, Anne
A1  - Schacher, Beate
A1  - Oremek, Gerhard
A1  - Kaiser, Frank
A1  - Wohlfeil, Martin
A1  - Nibali, Luigi
T1  - Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis
T2  - Clinical oral investigations
N2  - Aim: Assessment of the effect of nonsurgical periodontal therapy on haematological parameters in patients with grades B (BP) and C periodontitis (CP).
Methods: Eight BP and 46 CP patients received full-mouth periodontal debridement within 48 h, if positive for Aggregatibacter actinomycetemcomitans with adjunctive systemic antibiotics (4 BP, 17 CP). Clinical data were collected prior and 12 weeks after periodontal therapy. Blood was sampled prior to and 1 day as well as 6 and 12 weeks after the first SD visit. Erythrocyte count, haemoglobin value, haematocrit (HCT), mean erythrocyte volume (MCV), mean corpuscular haemoglobin (MCH), MCH concentration (MCHC), platelets (PLT) and heat shock protein 27 (Hsp27) were assessed.
Results: Both groups showed significant clinical improvement (p < 0.05). Using univariate analysis, MCV was noticeably lower in CP than BP at all examinations, HCT only at baseline. For CP, MCHC was noticeably higher 12 weeks after SD than at baseline and 1 day (p ≤ 0.005) and Hsp27 increased noticeably at 1 day (p < 0.05). Repeated measures analysis of variance revealed African origin to be associated with lower MCV and female sex with lower MCHC.
Conclusion: Based on multivariate analysis, periodontal diagnosis (BP/CP) was not associated with haematological parameters measured in this study or serum Hsp27. In CP, nonsurgical periodontal therapy improved MCHC 12 weeks after SD. Also in CP Hsp27 was increased 1 day after SD.
KW  - Haematocrit
KW  - Mean erythrocyte volume
KW  - Number of platelets
KW  - Heat shock protein 27
KW  - Periodontitis grades B and C
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63735
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-637357
SN  - 1436-3771
N1  - Open Access funding provided by Projekt DEAL. This study was in part funded by the authors and their institutions and in part by grants of the German Society of Periodontology (DG PARO), the German Society of Dental, Oral, and Maxillofacial Medicine (DGZMK), the New Working Group for Periodontology (NAgP) (3 months examination) and the Freiherr Carl von Rothschild’sche Stiftung Carolinum, Frankfurt, Germany (analysis for heat shock proteins).
VL  - 24
IS  - 12
SP  - 4291
EP  - 4299
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -