TY  - JOUR
A1  - Agha, Bishr
A1  - Ahmad, Nura
A1  - Dawson, Daniel G.
A1  - Kohnen, Thomas
A1  - Schmack, Ingo
T1  - Refractive outcome and tomographic changes after Descemet membrane endothelial keratoplasty in pseudophakic eyes with Fuchs' endothelial dystrophy
T2  - International ophthalmology
N2  - Purpose: To analyze refractive and topographic changes secondary to Descemet membrane endothelial keratoplasty (DMEK) in pseudophakic eyes with Fuchs’ endothelial dystrophy (FED). Methods: Eighty-seven pseudophakic eyes of 74 patients who underwent subsequent DMEK surgery for corneal endothelial decompensation and associated visual impairment were included. Median post-operative follow-up time was 12 months (range: 3–26 months). Main outcome measures were pre- and post-operative manifest refraction, anterior and posterior corneal astigmatism, simulated keratometry (CASimK) and Q value obtained by Scheimpflug imaging. Secondary outcome measures included corrected distance visual acuity (CDVA), central corneal densitometry, central corneal thickness, corneal volume (CV), anterior chamber volume (ACV) and anterior chamber depth (ACD). Results: After DMEK surgery, mean pre-operative spherical equivalent (± SD) changed from + 0.04 ± 1.73 D to + 0.37 ± 1.30 D post-operatively (p = 0.06). CDVA, proportion of emmetropic eyes, ACV and ACD increased significantly during follow-up. There was also a significant decrease in posterior corneal astigmatism, central corneal densitometry, central corneal thickness and corneal volume over time (p = 0.001). Only anterior corneal astigmatism and simulated keratometry (CASimK) remained fairly stable after DMEK. Conclusion: Despite tendencies toward a hyperopic shift, changes in SE were not significant and refraction remained overall stable in pseudophakic patients undergoing DMEK for FED. Analysis of corneal parameters by Scheimpflug imaging mainly revealed changes in posterior corneal astigmatism pointing out the relevance of posterior corneal profile changes during edema resolution after DMEK.
KW  - DMEK
KW  - Refractive changes
KW  - Corneal tomography
KW  - Pseudophakia
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63591
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-635919
SN  - 1573-2630
N1  - Open Access funding enabled and organized by Projekt DEAL. This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. Prof. Thomas Kohnen is a consultant to and conducts research for J&J Vision (Abbott Medical Optics, Inc.), Novartis (Alcon Laboratories, Inc.), Oculentis GmbH, Avedro Inc., Oculus Optikgeräte GmbH, Presbia, Schwind Eye-Tech Solutions GmbH and Carl Zeiss Meditec AG; serves as a consultant for Allergan Inc., Bausch & Lomb, Dompé, Geuder AG, Med Update GmbH, Rayner, Santen GmbH, STAAR Surgical AG, Thea Pharma GmbH, TearLab Corp., Thieme Compliance GmbH, Ziemer Opthalmology GmbH; and has received research funding from Hoya Surgical Optics GmbH.
VL  - 41
IS  - 8
SP  - 2897
EP  - 2904
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht
ER  -