TY  - JOUR
A1  - Seiler, Alexander
A1  - Nöth, Ulrike
A1  - Hok, Pavel
A1  - Reiländer, Annemarie
A1  - Maiworm, Michelle
A1  - Baudrexel, Simon
A1  - Meuth, Sven
A1  - Rosenow, Felix
A1  - Steinmetz, Helmuth
A1  - Wagner, Marlies
A1  - Hattingen, Elke
A1  - Deichmann, Ralf
A1  - Gracien, René-Maxime
T1  - Multiparametric quantitative MRI in neurological diseases
T2  - Frontiers in neurology
N2  - Magnetic resonance imaging (MRI) is the gold standard imaging technique for diagnosis and monitoring of many neurological diseases. However, the application of conventional MRI in clinical routine is mainly limited to the visual detection of macroscopic tissue pathology since mixed tissue contrasts depending on hardware and protocol parameters hamper its application for the assessment of subtle or diffuse impairment of the structural tissue integrity. Multiparametric quantitative (q)MRI determines tissue parameters quantitatively, enabling the detection of microstructural processes related to tissue remodeling in aging and neurological diseases. In contrast to measuring tissue atrophy via structural imaging, multiparametric qMRI allows for investigating biologically distinct microstructural processes, which precede changes of the tissue volume. This facilitates a more comprehensive characterization of tissue alterations by revealing early impairment of the microstructural integrity and specific disease-related patterns. So far, qMRI techniques have been employed in a wide range of neurological diseases, including in particular conditions with inflammatory, cerebrovascular and neurodegenerative pathology. Numerous studies suggest that qMRI might add valuable information, including the detection of microstructural tissue damage in areas appearing normal on conventional MRI and unveiling the microstructural correlates of clinical manifestations. This review will give an overview of current qMRI techniques, the most relevant tissue parameters and potential applications in neurological diseases, such as early (differential) diagnosis, monitoring of disease progression, and evaluating effects of therapeutic interventions.
KW  - quantitative magnetic resonance imaging
KW  - neuroimaging
KW  - multiple sclerosis
KW  - brain imaging
KW  - epilepsy
KW  - neurodegeneration
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61085
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-610859
SN  - 1664-2295
VL  - 12
IS  - art. 640239
SP  - 1
EP  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -