TY  - JOUR
A1  - Vogler, Meike
A1  - Shanmugalingam, Senthan
A1  - Särchen, Vinzenz
A1  - Reindl, Lisa Marie
A1  - Grèze, Victoria
A1  - Buchinger, Leon
A1  - Kühn, Michael
A1  - Ullrich, Evelyn
T1  - Unleashing the power of NK cells in anticancer immunotherapy
T2  - Journal of molecular medicine
N2  - Due to their physiological role in removing damaged cells, natural killer (NK) cells represent ideal candidates for cellular immunotherapy in the treatment of cancer. Thereby, the cytotoxicity of NK cells is regulated by signals on both, the NK cells as well as the targeted tumor cells, and the interplay and balance of these signals determine the killing capacity of NK cells. One promising avenue in cancer treatment is therefore the combination of NK cell therapy with agents that either help to increase the killing capacity of NK cells or sensitize tumor cells to an NK cell-mediated attack. In this mini-review, we present different strategies that can be explored to unleash the potential of NK cell immunotherapy. In particular, we summarize how modulation of apoptosis signaling within tumor cells can be exploited to sensitize tumor cells to NK cell-mediated cytotoxicity.
KW  - Immunotherapy
KW  - Natural killer cells
KW  - Apoptosis
KW  - Cancer
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62619
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-626191
SN  - 1432-1440
N1  - Open Access funding enabled and organized by Projekt DEAL. This work has been supported by the Deutsche Forschungsge- meinschaft DFG (CRC 1292 / IRTG).
VL  - 2021
IS  - online version before inclusion in an issue
PB  - Springer
CY  - Berlin; Heidelberg; New York, NY
ER  -