TY  - JOUR
A1  - Hahn, Martina
A1  - Roll, Sibylle C.
T1  - The influence of pharmacogenetics on the clinical relevance of pharmacokinetic drug–drug interactions: drug–gene, drug–gene–gene and drug–drug–gene interactions
T2  - Pharmaceuticals
N2  - Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event. This is because the clinical relevance of drug–drug interactions also depends on the genetic profile of the patient. If inhibitors or inducers of drug metabolising enzymes (e.g., CYP and UGT) are added to the drug therapy, phenoconcversion can occur. This leads to a genetic phenotype that mismatches the observable phenotype. Drug–drug–gene and drug–gene–gene interactions influence the toxicity and/or ineffectivness of the drug therapy. To date, there have been limited published studies on the impact of genetic variations on drug–drug interactions. This review discusses the current evidence of drug–drug–gene interactions, as well as drug–gene–gene interactions. Phenoconversion is explained, the and methods to calculate the phenotypes are described. Clinical recommendations are given regarding the integratation of the PGx results in the assessment of the relevance of drug interactions in the future.
KW  - drug–drug interactions
KW  - drug–gene interactions
KW  - drug–g–gene interactions
KW  - phenoconversion
KW  - pharmacogenetics
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62328
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-623287
SN  - 1424-8247
VL  - 14
IS  - 5, art. 487
SP  - 1
EP  - 15
PB  - MDPI
CY  - Basel
ER  -