TY  - JOUR
A1  - Ouahrouch, Abdelaaziz
A1  - Taourirte, Moha
A1  - Schols, Dominique
A1  - Snoeck, Robert
A1  - Andrei, Graciela
A1  - Engels, Joachim W.
A1  - Lazrek, Hassan B.
T1  - Design, synthesis, and antiviral activity of novel ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates
T2  - Archiv der Pharmazie
N2  - A novel series of ribonucleosides of 1,2,3-triazolylbenzyl-aminophosphonates was synthesized through the Kabachnik–Fields reaction using I2 as catalyst followed by copper-catalyzed cycloaddition of the azide–alkyne reaction (CuAAC). All structures of the newly prepared compounds were characterized by 1H NMR, 13C NMR, and HRMS spectra. The structures of 2e, 2f, 3d, and 3g were further confirmed by X-ray diffraction analysis. These compounds were tested against various strains of DNA and RNA viruses; compounds 4b and 4c showed a modest inhibitory activity against respiratory syncytial virus (RSV) and compound 4h displayed modest inhibitory activity against Coxsackie virus B4.
KW  - 1,2,3-Triazoles
KW  - α-Aminophosphonates
KW  - Antiviral activity
KW  - Kabachnik–Fields reaction
KW  - Ribonucleosides
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39569
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-395691
N1  - © 2015 The Authors. Archiv der Pharmazie Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
VL  - 349
IS  - 1
SP  - 30
EP  - 41
PB  - Wiley-VCH
ER  -