TY  - JOUR
A1  - Schulte-Oehlmann, Ulrike
A1  - Albanis, Triantafyllos
A1  - Allera, Axel
A1  - Bachmann, Jean
A1  - Berntsson, Pia
A1  - Beresford, Nicola
A1  - Carnevali, Daniela Candia
A1  - Ciceri, Francesca
A1  - Dagnac, Thierry
A1  - Falandysz, Jerzy
A1  - Galassi, Silvana
A1  - Hala, David
A1  - Janer, Gemma
A1  - Jeannot, Roger
A1  - Jobling, Susan
A1  - King, Isabella
A1  - Klingmüller, Dietrich
A1  - Kloas, Werner
A1  - Kusk, Kresten Ole
A1  - Levada, Ramon
A1  - Lo, Susan
A1  - Lutz, Ilka
A1  - Oehlmann, Jörg
A1  - Oredsson, Stina
A1  - Porte, Cinta
A1  - Rand-Weaver, Marian
A1  - Sakkas, Vasilis
A1  - Sugni, Michela
A1  - Tyler, Charles
A1  - Aerle, Ronny van
A1  - Ballegoy, Christoph van
A1  - Wollenberger, Leah
T1  - COMPRENDO : focus and approach
T2  - Environmental health perspectives
N2  - Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body’s signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that “the dose makes the poison” may not always be the case because some EDCs do not induce the classical dose–response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters—Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates).
KW  - androgens
KW  - antiandrogens
KW  - endocrine disruptor
KW  - environmental health
KW  - molecular screening
KW  - phylogenetic approach
KW  - wildlife exposure
Y1  - 2007
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/966
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-45218
SN  - 1552-9924
SN  - 0091-6765
N1  - This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI doi: 10.1289/ehp.8060.
VL  - 114
IS  - Supplement 1
SP  - 98
EP  - 100
PB  - National Institute of Environmental Health Sciences
CY  - Research Triangle Park, N.C. [u. a.]
ER  -