TY  - JOUR
A1  - Rother, Michael
A1  - Krzycki, Joseph A.
T1  - Selenocysteine, pyrrolysine and the unique energy metabolism of methanogenic archaea
T2  - Archaea
N2  - Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine- and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism.
Y1  - 2010
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/8112
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-80642
N1  - Copyright © 2010 Michael Rother and Joseph A. Krzycki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2010
IS  - Article ID 453642
PB  - Hindawi Publishing Corporation
ER  -