TY  - JOUR
A1  - Bernd, Johannes
A1  - Terfort, Andreas
T1  - Flow electrosynthesis for efficient O-trifluoromethylation of electron-deficient phenols
T2  - Electrochemistry communications
N2  - A sustainable strategy for O-trifluoromethylation of electron-deficient phenols by combining electrochemical synthesis with flow technology is presented. The reaction is optimized by screening experiments to establish a fast and efficient flow protocol. Simultaneous anodic oxidation of Langlois reagent and the phenols in a micro flow cell leads to direct preparation of trifluoromethyl ethers in yields up to 90%. This one-step protocol is tolerant of several functional groups, shows good regioselectivity and works without any chemical oxidants and catalysts by using electrical current as an inexpensive and sustainable reagent.
KW  - Organic electrochemistry
KW  - Flow chemistry
KW  - Trifluoromethylation
KW  - Trifluoromethoxy groups
KW  - Green chemistry
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79070
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-790701
SN  - 1388-2481
VL  - 154
IS  - 107545
PB  - Elsevier
CY  - Amsterdam
ER  -