TY  - JOUR
A1  - Höh, Robert Benedikt
A1  - Hohenhorst, Jan L.
A1  - Flammia, Rocco Simone
A1  - Horlemann, Benedikt
A1  - Sorce, Gabriele
A1  - Chierigo, Francesco
A1  - Tian, Zhe
A1  - Saad, Fred
A1  - Graefen, Markus
A1  - Gallucci, Michele
A1  - Briganti, Alberto
A1  - Terrone, Carlo
A1  - Shariat, Shahrokh F.
A1  - Kluth, Luis
A1  - Becker, Andreas
A1  - Chun, Felix
A1  - Karakiewicz, Pierre I.
T1  - Cancer-specific mortality after radical prostatectomy vs external beam radiotherapy in high-risk Hispanic/Latino prostate cancer patients
T2  - International urology and nephrology
N2  - Purpose: To test for differences in cancer-specific mortality (CSM) rates in Hispanic/Latino prostate cancer patients according to treatment type, radical prostatectomy (RP) vs external beam radiotherapy (EBRT).
Methods: Within the Surveillance, Epidemiology, and End Results database (2010–2016), we identified 2290 NCCN (National Comprehensive Cancer Network) high-risk (HR) Hispanic/Latino prostate cancer patients. Of those, 893 (39.0%) were treated with RP vs 1397 (61.0%) with EBRT. First, cumulative incidence plots and competing risks regression models tested for CSM differences after adjustment for other cause mortality (OCM). Second, cumulative incidence plots and competing risks regression models were refitted after 1:1 propensity score matching (according to age, PSA, biopsy Gleason score, cT-stage, cN-stage).
Results: In NCCN HR patients, 5-year CSM rates for RP vs EBRT were 2.4 vs 4.7%, yielding a multivariable hazard ratio of 0.37 (95% CI 0.19–0.73, p = 0.004) favoring RP. However, after propensity score matching, the hazard ratio of 0.54 was no longer statistically significant (95% CI 0.21–1.39, p = 0.2).
Conclusion: Without the use of strictest adjustment for population differences, NCCN high-risk Hispanic/Latino prostate cancer patients appear to benefit more of RP than EBRT. However, after strictest adjustment for baseline patient and tumor characteristics between RP and EBRT cohorts, the apparent CSM benefit of RP is no longer statistically significant. In consequence, in Hispanic/Latino NCCN high-risk patients, either treatment modality results in similar CSM outcome.
KW  - High-risk prostate cancer
KW  - Radical prostatectomy
KW  - External beam radiotherapy
KW  - Hispanic–Latino race/ethnicity
KW  - Cancer-specific survival
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69552
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-695528
SN  - 1573-2584
N1  - Open Access funding enabled and organized by Projekt DEAL.
N1  - All data generated for this analysis were from the SEER database. The code for the analyses will be made available upon request.
VL  - 54
IS  - 1
SP  - 81
EP  - 87
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht [u.a.]
ER  -