TY  - JOUR
A1  - Fulda, Simone
A1  - Rajalingam, Krishnaraj
A1  - Đikić, Ivan
T1  - Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications
T2  - EMBO molecular medicine
N2  - Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes. What was once regarded as a mere signal for protein degradation has turned out to be a major regulator of molecular signalling networks. Deregulation of ubiquitin signalling is closely associated with various human pathologies. Here, we summarize the current knowledge of ubiquitin signalling in immune deficiencies and cancer as well as the available therapeutic strategies targeting the ubiquitin system in combating these pathogenic conditions.
KW  - apoptosis
KW  - cell death
KW  - inflammation
KW  - NF-κB
KW  - ubiquitin
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28771
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-287713
SN  - 1715-4684
SN  - 1757-4676
N1  - Copyright © 2012 EMBO Molecular Medicine. This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
VL  - 4
IS  - 7
SP  - 545
EP  - 556
PB  - Wiley-VCH
CY  - Weinheim
ER  -