TY  - JOUR
A1  - Hamzehpour, Lara
A1  - Bohn, Tamara
A1  - Dutsch, Valentin
A1  - Jaspers, Lucia
A1  - Grimm, Oliver
T1  - From brain to body: exploring the connection between altered reward processing and physical fitness in schizophrenia
T2  - Psychiatry research
N2  - Understanding the underlying mechanisms that link psychopathology and physical comorbidities in schizophrenia is crucial since decreased physical fitness and overweight pose major risk factors for cardio-vascular diseases and decrease the patients’ life expectancies. We hypothesize that altered reward anticipation plays an important role in this. We implemented the Monetary Incentive Delay task in a MR scanner and a fitness test battery to compare schizophrenia patients (SZ, n = 43) with sex- and age-matched healthy controls (HC, n = 36) as to reward processing and their physical fitness. We found differences in reward anticipation between SZs and HCs, whereby increased activity in HCs positively correlated with overall physical condition and negatively correlated with psychopathology. On the other handy, SZs revealed stronger activity in the posterior cingulate cortex and in cerebellar regions during reward anticipation, which could be linked to decreased overall physical fitness. These findings demonstrate that a dysregulated reward system is not only responsible for the symptomatology of schizophrenia, but might also be involved in physical comorbidities which could pave the way for future lifestyle therapy interventions.
KW  - Reward system
KW  - fMRI
KW  - MID task
KW  - Reward anticipation
KW  - Physical comorbidities
KW  - Cerebellum
Y1  - 2024
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83529
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-835299
SN  - 0165-1781
VL  - 335
IS  - 115877
PB  - Elsevier
CY  - Amsterdam
ER  -