TY  - JOUR
A1  - Schneider, Andreas
A1  - Blatzer, Michael
A1  - Posch, Wilfried
A1  - Schubert, Ralf
A1  - Lass-Flörl, Cornelia
A1  - Schmidt, Stanislaw
A1  - Lehrnbecher, Thomas
T1  - Aspergillus fumigatus responds to natural killer (NK) cells with upregulation of stress related genes and inhibits the immunoregulatory function of NK cells
T2  - OncoTarget
N2  - Natural Killer (NK) cells are active against Aspergillus fumigatus, which in turn is able to impair the host defense. Unfortunately, little is known on the mutual interaction of NK cells and A. fumigatus. We coincubated human NK cells with A. fumigatus hyphae and assessed the gene expression and protein concentration of selected molecules. We found that A. fumigatus up-regulates the gene expression of pro-inflammatory molecules in NK cells, but inhibited the release of these molecules resulting in intracellular accumulation and limited extracellular availability. A. fumigatus down-regulatedmRNA levels of perforin in NK cells, but increased its intra- and extracellular protein concentration. The gene expression of stress related molecules of A. fumigatus such as heat shock protein hsp90 was up-regulated by human NK cells. Our data characterize for the first time the immunosuppressive effect of A. fumigatus on NK cells and may help to develop new therapeutic antifungal strategies.
KW  - Aspergillus fumigatus
KW  - human natural killer cell
KW  - gene expression
KW  - perforin
KW  - cytokine
KW  - Immunology and Microbiology Section
KW  - Immune response
KW  - Immunity
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45681
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-456811
SN  - 1949-2553
N1  - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
VL  - 7
IS  - 44
SP  - 71062
EP  - 71071
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -