TY  - JOUR
A1  - Amico, Francesco
A1  - O’Hanlon, Erik
A1  - Kraft, Dominik
A1  - Oertel-Knöchel, Viola
A1  - Clarke, Mary
A1  - Kelleher, Ian
A1  - Higgins, Niamh
A1  - Coughlan, Helen
A1  - Creegan, Daniel
A1  - Heneghan, Mark
A1  - Power, Emmet
A1  - Power, Lucy
A1  - Ryan, Jessica
A1  - Frodl, Thomas
A1  - Cannon, Mary
T1  - Functional connectivity anomalies in adolescents with psychotic symptoms
T2  - PLoS one
N2  - Background: Previous magnetic resonance imaging (MRI) research suggests that, prior to the onset of psychosis, high risk youths already exhibit brain abnormalities similar to those present in patients with schizophrenia.
Objectives: The goal of the present study was to describe the functional organization of endogenous activation in young adolescents who report auditory verbal hallucinations (AVH) in view of the “distributed network” hypothesis of psychosis. We recruited 20 young people aged 13–16 years who reported AVHs and 20 healthy controls matched for age, gender and handedness from local schools.
Methods: Each participant underwent a semi-structured clinical interview and a resting state (RS) neuroimaging protocol. We explored functional connectivity (FC) involving three different networks: 1) default mode network (DMN) 2) salience network (SN) and 3) central executive network (CEN). In line with previous findings on the role of the auditory cortex in AVHs as reported by young adolescents, we also investigated FC anomalies involving both the primary and secondary auditory cortices (A1 and A2, respectively).
Further, we explored between-group inter-hemispheric FC differences (laterality) for both A1 and A2. Compared to the healthy control group, the AVH group exhibited FC differences in all three networks investigated. Moreover, FC anomalies were found in a neural network including both A1 and A2. The laterality analysis revealed no between-group, inter-hemispheric differences.
Conclusions: The present study suggests that young adolescents with subclinical psychotic symptoms exhibit functional connectivity anomalies directly and indirectly involving the DMN, SN, CEN and also a neural network including both primary and secondary auditory cortical regions.
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42887
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-428879
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268394
SN  - 1932-6203
N1  - Copyright: © 2017 Amico et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 12
IS  - (1): e0169364
SP  - 1
EP  - 17
PB  - PLoS
CY  - Lawrence, Kan.
ER  -