TY  - JOUR
A1  - Lewis, Christopher Murphy
A1  - Bosman, Conrado A.
A1  - Fries, Pascal
T1  - Recording of brain activity across spatial scales
T2  - Current Opinion in Neurobiology
N2  - Brain activity reveals exquisite coordination across spatial scales, from local microcircuits to brain-wide networks. Understanding how the brain represents, transforms and communicates information requires simultaneous recordings from distributed nodes of whole brain networks with single-cell resolution. Realizing multi-site recordings from communicating populations is hampered by the need to isolate clusters of interacting cells, often on a day-to-day basis. Chronic implantation of multi-electrode arrays allows long-term tracking of activity. Lithography on thin films provides a means to produce arrays of variable resolution, a high degree of flexibility, and minimal tissue displacement. Sequential application of surface arrays to monitor activity across brain-wide networks and subsequent implantation of laminar arrays to target specific populations enables continual refinement of spatial scale while maintaining coverage.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30632
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-306328
SN  - 0959-4388
N1  - © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
VL  - 32
SP  - 68
EP  - 77
PB  - Current Biology
CY  - Philadelphia, Pa
ER  -