TY  - JOUR
A1  - Segarra, Marta
A1  - Kirchmaier, Bettina C.
A1  - Acker-Palmer, Amparo
T1  - A vascular perspective on neuronal migration
T2  - Mechanisms of Development
N2  - During CNS development and adult neurogenesis, immature neurons travel from the germinal zones towards their final destination using cellular substrates for their migration. Classically, radial glia and neuronal axons have been shown to act as physical scaffolds to support neuroblast locomotion in processes known as gliophilic and neurophilic migration, respectively (Hatten, 1999; Marin and Rubenstein, 2003; Rakic, 2003). In adulthood, long distance neuronal migration occurs in a glial-independent manner since radial glia cells differentiate into astrocytes after birth. A series of studies highlight a novel mode of neuronal migration that uses blood vessels as scaffolds, the so-called vasophilic migration. This migration mode allows neuroblast navigation in physiological and also pathological conditions, such as neuronal precursor migration after ischemic stroke or cerebral invasion of glioma tumor cells. Here we review the current knowledge about how vessels pave the path for migrating neurons and how trophic factors derived by glio-vascular structures guide neuronal migration both during physiological as well as pathological processes
KW  - Endothelium
KW  - Vasophilic migration
KW  - Neuronal migration
KW  - Neuroblasts
KW  - Ischemia
KW  - Gliom
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/41896
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-418962
N1  - © 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 138
SP  - 17
EP  - 25
ER  -