TY  - JOUR
A1  - Windisch, Roland
A1  - Pirschtat, Nina
A1  - Kellner, Christian
A1  - Chen-Wichmann, Linping
A1  - Lausen, Jörn
A1  - Humpe, Andreas
A1  - Krause, Daniela Sandra
A1  - Wichmann, Christian
T1  - Oncogenic deregulation of cell adhesion molecules in leukemia
T2  - Cancers
N2  - Numerous cell–cell and cell–matrix interactions within the bone marrow microenvironment enable the controlled lifelong self-renewal and progeny of hematopoietic stem and progenitor cells (HSPCs). On the cellular level, this highly mutual interaction is granted by cell adhesion molecules (CAMs) integrating differentiation, proliferation, and pro-survival signals from the surrounding microenvironment to the inner cell. However, cell–cell and cell–matrix interactions are also critically involved during malignant transformation of hematopoietic stem/progenitor cells. It has become increasingly apparent that leukemia-associated gene products, such as activated tyrosine kinases and fusion proteins resulting from chromosomal translocations, directly regulate the activation status of adhesion molecules, thereby directing the leukemic phenotype. These observations imply that interference with adhesion molecule function represents a promising treatment strategy to target pre-leukemic and leukemic lesions within the bone marrow niche. Focusing on myeloid leukemia, we provide a current overview of the mechanisms by which leukemogenic gene products hijack control of cellular adhesion to subsequently disturb normal hematopoiesis and promote leukemia development.
KW  - adhesion
KW  - leukemia
KW  - oncogene
KW  - integrin
KW  - CAM
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48874
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488740
SN  - 2072-6694
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
VL  - 11
IS  - 3, Art. 311
SP  - 1
EP  - 18
PB  - MDPI
CY  - Basel
ER  -