TY  - INPR
A1  - Parra-Rojas, César
A1  - Nguyen, Van Kinh
A1  - Hernández-Mejı́a, Gustavo
A1  - Hernández-Vargas, Esteban A.
T1  - Neuraminidase inhibitors is it time to call it a day?
T2  - bioRxiv
N2  - Stockpiling neuraminidase inhibitors (NAIs) such as oseltamivir and zanamivir is part of a global effort to be prepared for an influenza pandemic. However, the contribution of NAIs for treatment and prevention of influenza and its complications is largely debatable. Here, we developed a transparent mathematical modelling setting to analyse the impact of NAIs on influenza disease at within-host and population level. Analytical and simulation results indicate that even assuming unrealistically high efficacies for NAIs, drug intake starting on the onset of symptoms has a negligible effect on an individual's viral load and symptoms score. Increasing NAIs doses does not provide a better outcome as is generally believed. Considering Tamiflu's pandemic regimen for prophylaxis, different multiscale simulation scenarios reveal modest reductions in epidemic size despite high investments in stockpiling. Our results question the use of NAIs in general to treat influenza as well as the respective stockpiling by regulatory authorities.
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72449
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-724490
IS  - 245175
ER  -