TY  - JOUR
A1  - Mahmoudi, Scherwin
A1  - Grünewald, Leon David
A1  - Koch, Vitali
A1  - Bernatz, Simon
A1  - Martin, Simon S.
A1  - Engelskirchen, Lara
A1  - Radic, Ivana
A1  - Bucolo, Giuseppe
A1  - D’Angelo, Tommaso
A1  - Gotta, Jennifer
A1  - Mader, Christoph
A1  - Pinto dos Santos, Daniel
A1  - Scholtz, Jan-Erik
A1  - Gruber-Rouh, Tatjana
A1  - Eichler, Katrin
A1  - Vogl, Thomas J.
A1  - Booz, Christian
A1  - Yel, Ibrahim
T1  - Potential of dual-energy CT-based collagen maps for the assessment of disk degeneration in the lumbar spine
T2  - Academic radiology
N2  - Rationale and Objectives: Lumbar disk degeneration is a common condition contributing significantly to back pain. The objective of the study was to evaluate the potential of dual-energy CT (DECT)-derived collagen maps for the assessment of lumbar disk degeneration.
Patients and Methods: We conducted a retrospective analysis of 127 patients who underwent dual-source DECT and MRI of the lumbar spine between 07/2019 and 10/2022. The level of lumbar disk degeneration was categorized by three radiologists as follows: no/mild (Pfirrmann 1&2), moderate (Pfirrmann 3&4), and severe (Pfirrmann 5). Recall (sensitivity) and accuracy of DECT collagen maps were calculated. Intraclass correlation coefficient (ICC) was used to evaluate inter-reader reliability. Subjective evaluations were performed using 5-point Likert scales for diagnostic confidence and image quality.
Results: We evaluated a total of 762 intervertebral disks from 127 patients (median age, 69.7 (range, 23.0–93.7), female, 56). MRI identified 230 non/mildly degenerated disks (30.2%), 484 moderately degenerated disks (63.5%), and 48 severely degenerated disks (6.3%). DECT collagen maps yielded an overall accuracy of 85.5% (1955/2286). Recall (sensitivity) was 79.3% (547/690) for the detection of no/mild lumbar disk degeneration, 88.7% (1288/1452) for the detection of moderate disk degeneration, and 83.3% (120/144) for the detection of severe disk degeneration (ICC = 0.9). Subjective evaluations of DECT collagen maps showed high diagnostic confidence (median 4) and good image quality (median 4).
Conclusion: The use of DECT collagen maps to distinguish different stages of lumbar disk degeneration may have clinical significance in the early diagnosis of disk-related pathologies in patients with contraindications for MRI or in cases of unavailability of MRI.
KW  - DECT
KW  - Computed tomography
KW  - Collagen Maps
KW  - Spine
KW  - Lumbar Disk Degeneration
KW  - Post-processing
Y1  - 2024
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83468
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-834686
UR  - https://www.sciencedirect.com/science/article/pii/S1076633224001272
SN  - 1076-6332
VL  - 2024
IS  - In Press, Corrected Proof
PB  - Elsevier
CY  - Amsterdam
ER  -