TY  - JOUR
A1  - Deco, Gustavo
A1  - Tagliazucchi, Enzo
A1  - Laufs, Helmut
A1  - Sanjuán, Ana Maria
A1  - Kringelbach, Morten L.
T1  - Novel intrinsic ignition method measuring local-global integration characterizes wakefulness and deep sleep
T2  - eNeuro
N2  - A precise definition of a brain state has proven elusive. Here, we introduce the novel local-global concept of intrinsic ignition characterizing the dynamical complexity of different brain states. Naturally occurring intrinsic ignition events reflect the capability of a given brain area to propagate neuronal activity to other regions, giving rise to different levels of integration. The ignitory capability of brain regions is computed by the elicited level of integration for each intrinsic ignition event in each brain region, averaged over all events. This intrinsic ignition method is shown to clearly distinguish human neuroimaging data of two fundamental brain states (wakefulness and deep sleep). Importantly, whole-brain computational modelling of this data shows that at the optimal working point is found where there is maximal variability of the intrinsic ignition across brain regions. Thus, combining whole brain models with intrinsic ignition can provide novel insights into underlying mechanisms of brain states.
KW  - whole-brain modeling
KW  - neuroimaging
KW  - ignition
KW  - metastability
KW  - integration
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43914
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-439149
SN  - 2373-2822
N1  - Copyright © 2017 Deco et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed
VL  - 4
IS  - 5, ENEURO.0106-17.2017
SP  - 1
EP  - 12
PB  - Society for Neuroscience
CY  - Washington, DC
ER  -