TY  - JOUR
A1  - Gubas, Andrea
A1  - Đikić, Ivan
T1  - ER remodeling via ER-phagy
T2  - Molecular Cell
N2  - The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER membrane is highly dynamic, which affects many cellular processes that take place within the ER. One such process is ER-phagy, a selective degradation of ER fragments (including membranes and luminal content), which serves to preserve the size of ER while adapting its morphology under basal and stress conditions. In order to be degraded, the ER undergoes selective fragmentation facilitated by specialized ER-shaping proteins that also act as ER-phagy receptors. Their ability to sense and induce membrane curvature, as well as to bridge the ER with autophagy machinery, allows for a successful ER fragmentation and delivery of these fragments to the lysosome for degradation and recycling. In this review, we provide insights into ER-phagy from the perspective of membrane remodeling. We highlight the importance of ER membrane dynamics during ER-phagy and emphasize how its dysregulation reflects on human physiology and pathology.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78284
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-782841
SN  - 1097-2765
VL  - 82
IS  - 8
SP  - 1492
EP  - 1500
PB  - Elsevier
CY  - Amsterdam
ER  -