TY  - JOUR
A1  - Yakulov, Toma
A1  - Todkar, Abhijeet P.
A1  - Slanchev, Krasimir
A1  - Wiegel, Johannes
A1  - Bona, Alexandra
A1  - Groß, Martin
A1  - Scholz, Alexander
A1  - Hess, Isabell
A1  - Wurditsch, Anne
A1  - Grahammer, Florian
A1  - Huber, Tobias
A1  - Lecaudey, Virginie
A1  - Bork, Tillmann
A1  - Hochrein, Jochen
A1  - Börries, Melanie
A1  - Leenders, Justine
A1  - Tullio, Pascal de
A1  - Jouret, François
A1  - Kramer-Zucker, Albrecht
A1  - Walz, Gerd
T1  - CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
T2  - Nature Communications
N2  - Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as candidates involved in the repair process. Zebrafish embryos with cxcl12a, cxcr4b, or myca deficiency display repair abnormalities, confirming their role in response to injury. In mice with a kidney-specific knockout, Cxcl12 and Myc gene deletions suppress mitochondrial metabolism and glycolysis, and delay the recovery after ischemia/reperfusion injury. Probing these observations in zebrafish reveal that inhibition of glycolysis slows fast migrating cells and delays the repair after injury, but does not affect the slow cell movements during kidney development. Our findings demonstrate that Cxcl12 and Myc facilitate glycolysis to promote fast migratory responses during development and repair, and potentially also during tumor invasion and metastasis.
KW  - Developmental biology
KW  - Nephrons
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/47113
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-471131
SN  - 2041-1723
N1  - Rights and permissions: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
VL  - 9
IS  - 1, Art. 3660
SP  - 1
EP  - 15
PB  - Nature Publishing Group UK
CY  - [London]
ER  -