TY  - JOUR
A1  - Koch, Alexander
A1  - Pfeilschifter, Josef
A1  - Huwiler, Andrea
T1  - Sphingosine 1-phosphate in renal diseases
T2  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.
KW  - Sphingosine 1-phosphate
KW  - Kidney disease
KW  - Diabetic nephropathy
KW  - Glomerulonephritis
KW  - Ischemia-reperfusion injury
KW  - Wilms tumor
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31662
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-316628
SN  - 1421-9778
SN  - 1015-8987
N1  - This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (www.karger.com/OA-license), applicable to the online version of the article only. Distribution for non-commercial purposes only.
VL  - 31
IS  - 6
SP  - 745
EP  - 760
PB  - Karger
CY  - Basel
ER  -