TY  - JOUR
A1  - Batarfi, AbdulAziz
A1  - Alenezi, Haitham
A1  - Alshehri, Abdulrahman
A1  - Balelah, Saud
A1  - Kazim, Hameedullah
A1  - Algthami, Mohammed
A1  - Hussain, Mariam M.
A1  - Alshehri, Nada
A1  - Alsharif, Rahaf
A1  - Ashour, Hadeel
A1  - Althobaiti, Mutaz
A1  - Alotaibi, Shomokh
A1  - Steinmetz, Helmuth
A1  - Förch, Christian
T1  - Patient-guided modifications of oral anticoagulant drug intake during Ramadan fasting: a multicenter cross-sectional study
T2  - Journal of thrombosis and thrombolysis
N2  - Fasting Ramadan is known to influence patients’ medication adherence. Data on patients’ behavior to oral anticoagulant (OAC) drug intake during Ramadan is missing. We aimed to determine patient-guided modifications of OAC medication regimen during Ramadan and to evaluate its consequences. A multicenter cross-sectional study conducted in Saudi Arabia. Data were collected shortly after Ramadan 2019. Participants were patients who fasted Ramadan and who were on long-term anticoagulation. Patient-guided medication changes during Ramadan in comparison to the regular intake schedule before Ramadan were recorded. Modification behavior was compared between twice daily (BID) and once daily (QD) treatment regimens. Rates of hospital admission during Ramadan were determined. We included 808 patients. During Ramadan, 53.1% modified their intake schedule (31.1% adjusted intake time, 13.2% skipped intakes, 2.2% took double dosing). A higher frequency of patient-guided modification was observed in patients on BID regimen compared to QD regimen. During Ramadan, 11.3% of patients were admitted to hospital. Patient-guided modification was a strong predictor for hospital admission. Patient-guided modification of OAC intake during Ramadan is common, particularly in patients on BID regimen. It increases the risk of hospital admission during Ramadan. Planning of OAC intake during Ramadan and patient education on the risk of low adherence are advisable.
KW  - Oral anticoagulation
KW  - Ramadan
KW  - Fasting
KW  - Saudi Arabia
KW  - Adherence
KW  - Education
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63693
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-636939
SN  - 1573-742X
N1  - Open Access funding provided by Projekt DEAL.
VL  - 51
IS  - 2
SP  - 485
EP  - 493
PB  - Springer Science + Business Media B.V
CY  - Dordrecht [u.a.]
ER  -