TY  - JOUR
A1  - Lohaus, Fabian
A1  - Linge, Annett
A1  - Tinhofer, Inge
A1  - Budach, Volker
A1  - Gkika, Eleni
A1  - Stuschke, Martin
A1  - Balermpas, Panagiotis
A1  - Rödel, Claus
A1  - Avlar, Melanie
A1  - Grosu, Anca-Ligia
A1  - Abdollahi, Amir
A1  - Debus, Jürgen
A1  - Bayer, Christine
A1  - Belka, Claus
A1  - Pigorsch, Steffi
A1  - Combs, Stephanie
A1  - Mönnich, David
A1  - Zips, Daniel
A1  - Neubeck, Cläre von
A1  - Baretton, Gustavo Bruno
A1  - Löck, Steffen
A1  - Thames, Howard D.
A1  - Krause, Mechthild
A1  - Baumann, Michael
T1  - HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
T2  - Radiotherapy & Oncology
N2  - Objective: To investigate the impact of HPV status in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received surgery and cisplatin-based postoperative radiochemotherapy.
Materials and methods: For 221 patients with locally advanced squamous cell carcinoma of the hypopharynx, oropharynx or oral cavity treated at the 8 partner sites of the German Cancer Consortium, the impact of HPV DNA, p16 overexpression and p53 expression on outcome were retrospectively analysed. The primary endpoint was loco-regional tumour control; secondary endpoints were distant metastases and overall survival.
Results: In the total patient population, univariate analyses revealed a significant impact of HPV16 DNA positivity, p16 overexpression, p53 positivity and tumour site on loco-regional tumour control. Multivariate analysis stratified for tumour site showed that positive HPV 16 DNA status correlated with loco-regional tumour control in patients with oropharyngeal carcinoma (p = 0.02) but not in the oral cavity carcinoma group. Multivariate evaluation of the secondary endpoints in the total population revealed a significant association of HPV16 DNA positivity with overall survival (p < 0.01) but not with distant metastases.
Conclusions: HPV16 DNA status appears to be a strong prognosticator of loco-regional tumour control after postoperative cisplatin-based radiochemotherapy of locally advanced oropharyngeal carcinoma and is now being explored in a prospective validation trial.
KW  - DKTK-ROG
KW  - HNSCC
KW  - HPV
KW  - Postoperative radiochemotherapy
KW  - p16
KW  - p53
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/40220
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-402205
SN  - 0167-8140
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
VL  - 113
IS  - 3
SP  - 317
EP  - 323
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  -