TY  - JOUR
A1  - Fischer, Fabian
A1  - Weil, Andrea
A1  - Hamann, Andrea
A1  - Osiewacz, Heinz D.
T1  - Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain
T2  - Nature Communications
N2  - Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. Our results show that the biological role of eukaryotic CLP proteases can be studied in an experimentally accessible model organism.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26339
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263393
SN  - 2041-1723
N1  - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
VL  - 4
IS  - 1397
PB  - Nature Publishing Group
CY  - London
ER  -