TY  - JOUR
A1  - Mikolas, Pavol
A1  - Bröckel, Kyra
A1  - Vogelbacher, Christoph
A1  - Müller, Dirk K.
A1  - Marxen, Michael
A1  - Berndt, Christina
A1  - Sauer, Cathrin
A1  - Jung, Stine
A1  - Fröhner, Juliane Hilde
A1  - Fallgatter, Andreas J.
A1  - Ethofer, Thomas
A1  - Rau, Anne Katrin
A1  - Kircher, Tilo
A1  - Falkenberg, Dania Irina
A1  - Lambert, Martin
A1  - Kraft, Vivien
A1  - Leopold, Karolina
A1  - Bechdolf, Andreas
A1  - Reif, Andreas
A1  - Matura, Silke
A1  - Stamm, Thomas
A1  - Bermpohl, Felix
A1  - Fiebig, Jana
A1  - Juckel, Georg
A1  - Flasbeck, Vera
A1  - Correll, Christoph U.
A1  - Ritter, Philipp Stefan
A1  - Bauer, Michael
A1  - Jansen, Andreas
A1  - Pfennig, Andrea
T1  - Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease
T2  - Translational Psychiatry
N2  - In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant differences in the thickness of the left pars opercularis (Cohen’s d = 0.47, p = 0.024) between groups. The cortex was significantly thinner in high-risk individuals compared to those in the no-risk group (p = 0.011). We detected no differences in the hippocampal volume. Exploratory analyses revealed no significant differences in other cortical or subcortical regions. The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations. Structural alterations in prefrontal cortex might be a trait marker of bipolar risk. This is the largest structural MRI study of help-seeking individuals at increased risk of bipolar disorder.
KW  - Bipolar disorder
KW  - Diagnostic markers
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64561
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-645614
SN  - 2158-3188
N1  - Early-BipoLife is funded by the Federal Ministry of Education and Research (BMBF, grant numbers: 01EE1404A, 01EE1404E, and 01EE1404F). M.M. was supported by the Deutsche Forschungsgemeinschaft (DFG grant Nos. 178833530 [SFB 940] and 402170461 [TRR 265].
VL  - 11
IS  - art. 485
SP  - 1
EP  - 8
PB  - Nature Publishing Group
CY  - London
ER  -