TY - JOUR A1 - Bieber, Miriam A1 - Görgülü, Esra A1 - Schmidt, Daniela A1 - Zabel, Kirsten A1 - Etyemez, Semra A1 - Friedrichs, Benedikt A1 - Prvulovic, David A1 - Reif, Andreas A1 - Oertel-Knöchel, Viola T1 - Effects of body-oriented yoga: a RCT study for patients with major depressive disorder T2 - European archives of psychiatry and clinical neuroscience N2 - The major depressive disorder is one of the most common mental illnesses worldwide. Current treatment standards recommend a combined therapy with medication and psychotherapy. As an additive component and to further improvements in treatment, physical activity such as yoga may be integrated into conventional treatment. This study investigates the impact of a 3-month body-oriented yoga in patients with major depressive disorder (MDD). In total, n = 83 patients were included. An intervention group received a vigorous Ashtanga-Yoga three times a week. The waiting-list control group obtained a treatment as usual (TAU). As a primary outcome depression scores (Beck Depression Inventory-II (BDI-II), Montgomery Asberg Depression Rating Scale (MADRS)) were tested at three time points. Secondary outcome was the positive and negative affect [Positive and Negative Affect Scale (PANAS)] and remission rates. To analyze the data, multilevel models and effect sizes were conducted. The results showed an improvement in BDI-II scores for both groups over time [γ =  −  3.46, t(165) =  − 7.99, p < 0.001] but not between groups [γ = 0.98, t(164) = 1.12, p = 0.263]. An interaction effect (time x group) occurred for MADRS [γ = 2.10, t(164) = 2.10, p < 0.038]. Positive affects improved over time for both groups [γ = 1.65, t(165) = 4.03, p < 0.001]. Negative affects decreased for all over time [γ =  −  1.00, t(165) = − 2.51, p = 0.013]. There were no significant group differences in PANAS. Post hoc tests revealed a greater symptom reduction within the first 6 weeks for all measurements. The effect sizes for depression scores showed a positive trend. Remission rates indicated a significant improvement in the yoga group (BDI-II: 46.81%, MADRS: 17.02%) compared to the control group (BDI: 33.33%, MADRS: 8.33%). The findings suggest that there is a trendsetting additive effect of Ashtanga-Yoga after 3 months on psychopathology and mood with a greater improvement at the beginning of the intervention. Further research in this field can help to achieve more differentiated results. KW - Depression KW - MDD KW - Yoga KW - Exercise KW - Intervention Y1 - 2021 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63772 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-637728 SN - 1433-8491 N1 - Open Access funding enabled and organized by Projekt DEAL. VL - 271 IS - 7 SP - 1217 EP - 1229 PB - Springer CY - Darmstadt : Steinkopff ; Berlin ; Heidelberg ER -