TY  - JOUR
A1  - Bernd, Johannes
A1  - Werner, Philipp
A1  - Zeplichal, Marc
A1  - Terfort, Andreas
T1  - Electrochemical O-trifluoromethylation of electron-deficient phenols
T2  - Electrochemistry communications
N2  - A simple and sustainable one-step strategy for the preparation of electron-deficient aryl trifluoromethyl ethers (ArOCF3) from the corresponding phenols by electrochemical synthesis is presented. Anodic oxidation of trifluoromethane sulfinate (Langlois reagent) leads to direct O-trifluoromethylation of phenol-derivatives bearing fluorine, chlorine, bromine and nitrile substituents under mild conditions in yields up to 75% and in gram-scale. This electrochemical protocol provides an economic and green synthesis for an otherwise inaccessible class of molecules without the need for expensive or toxic reagents, oxidants or metal catalysts.
KW  - Organic electrochemistry
KW  - Anodic oxidation
KW  - Trifluoromethylation
KW  - Phenols
KW  - Langlois reagent
KW  - Green chemistry
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77915
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-779157
SN  - 1388-2481
VL  - 133
IS  - 107165
PB  - Elsevier
CY  - Amsterdam
ER  -