TY  - JOUR
A1  - Schumann, Lana
A1  - Wilken-Schmitz, Annett
A1  - Trautmann, Sandra
A1  - Vogel, Alexandra
A1  - Schreiber, Yannick
A1  - Hahnefeld, Lisa Katharina
A1  - Gurke, Robert
A1  - Geisslinger, Gerd
A1  - Tegeder, Irmgard
T1  - Increased fat taste preference in progranulin-deficient mice
T2  - Nutrients
N2  - Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary fats. Progranulin-deficient mice (Grn−/−) are moderately overweight during middle age. We therefore asked if there was a connection between progranulin/CD36 in the tongue and fat taste preferences. By using unbiased behavioral analyses in IntelliCages and Phenomaster cages we showed that progranulin-deficient mice (Grn−/−) developed a strong preference of fat taste in the form of 2% milk over 0.3% milk, and for diluted MCTs versus tap water. The fat preference in the 7d-IntelliCage observation period caused an increase of 10% in the body weight of Grn−/− mice, which did not occur in the wildtype controls. CD36 expression in taste buds was reduced in Grn−/− mice at RNA and histology levels. There were no differences in the plasma or tongue lipids of various classes including sphingolipids, ceramides and endocannabinoids. The data suggest that progranulin deficiency leads to a lower expression of CD36 in the tongue resulting in a stronger urge for fatty taste and fatty nutrition.
KW  - taste buds
KW  - lipids
KW  - progranulin
KW  - CD36
KW  - IntelliCage
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69276
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-692765
SN  - 2072-6643
N1  - The study was supported by the Deutsche Forschungsgemeinschaft (CRC1039 A03 to I.T. and Z01 to G.G., and CRC1080, C02 to I.T.) and by the Fraunhofer Cluster of Excellence for Immune-Mediated diseases, CIMD) (to G.G.).
VL  - 13
IS  - 11, art. 4125
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  -