TY  - JOUR
A1  - Maronde, Erik
A1  - Schilling, Arndt
A1  - Seitz, Sebastian
A1  - Schinke, Thorsten
A1  - Schmutz, Isabelle
A1  - Horst, Gijsbertus van der
A1  - Amling, Michael
A1  - Albrecht, Urs
T1  - The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation
T2  - PLoS one
N2  - Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation. Osteoblasts build new mineralized bone whereas osteoclasts degrade it thereby balancing bone formation. To evaluate the contribution of clock components in this process, we investigated mice mutant in clock genes for a bone volume phenotype. Methodology/Principal Findings: We found that Per2Brdm1 mutant mice as well as mice lacking Cry2-/- displayed significantly increased bone volume at 12 weeks of age, when bone turnover is high. Per2Brdm1 mutant mice showed alterations in parameters specific for osteoblasts whereas mice lacking Cry2-/- displayed changes in osteoclast specific parameters. Interestingly, inactivation of both Per2 and Cry2 genes leads to normal bone volume as observed in wild type animals. Importantly, osteoclast parameters affected due to the lack of Cry2, remained at the level seen in the Cry2-/- mutants despite the simultaneous inactivation of Per2. Conclusions/Significance: This indicates that Cry2 and Per2 affect distinct pathways in the regulation of bone volume with Cry2 influencing mostly the osteoclastic cellular component of bone and Per2 acting on osteoblast parameters.
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22599
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-114442
SN  - 1932-6203
N1  - Copyright: © 2010 Maronde et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 5
IS  - (7): e11527
SP  - 1
EP  - 8
PB  - PLoS
CY  - Lawrence, Kan.
ER  -