TY  - JOUR
A1  - Kumral, Deniz
A1  - Cesnaite, Elena
A1  - Beyer, Frauke
A1  - Hofmann, Simon M.
A1  - Hensch, Tilman
A1  - Sander, Christian
A1  - Hegerl, Ulrich
A1  - Haufe, Stefan
A1  - Villringer, Arno
A1  - Witte, A. Veronica
A1  - Nikulin, Vadim V.
T1  - Relationship between regional white matter hyperintensities and alpha oscillations in older adults
T2  - Neurobiology of aging
N2  - Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N = 907, 60–80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and long-range temporal correlations. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMHs affecting a spatial organization of alpha sources.
KW  - EEG
KW  - MRI
KW  - White matter hyperintensity
KW  - Aging
KW  - Alpha power
KW  - Resting-state
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63109
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-631099
SN  - 1558-1497
N1  - This work is supported by the European Union, the European Regional Development Fund, and the Free State of Saxony within the framework of the excellence initiative and LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig (project numbers 713-241202, 713-241202, 14505/2470, 14575/2470).
N1  - Anonymized data will be made available upon request through the application procedure carried out by the LIFE-Study administration (https://life.uni-leipzig.de/de/erwachsenen_kohorten/life_adult.html).
VL  - 112
SP  - 1
EP  - 11
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  -