TY  - JOUR
A1  - Kim-Wanner, Soo-Zin
A1  - Lee, Seo-Youn
A1  - Seifried, Erhard
A1  - Bönig, Halvard-Björn
T1  - Donor-intrinsic variables determine mobilization efficiency: analyses from a cohort of sixty twice-mobilized stem cell donors
T2  - Journal of translational medicine
N2  - Background: Healthy volunteer registry donors have become the backbone of stem cell transplantation programs. While most registrants will never become actual donors, a small minority are called upon twice, most commonly for the same patient because of poor graft function. Anecdotal evidence provides no hard reasons to disallow second-time mobilized apheresis, but few centers have treated enough two-time donors for definitive conclusions. Moreover, for reasons unknown, the efficiency of G-CSF varies greatly between donations.
Methods: Comparison of outcomes of first vs. second donations can formally confirm G-CSF responsiveness as intrinsically, likely genetically, determined. In our database, we identified 60 donors (1.3%) who received two cycles of G-CSF 24 days to 4 years apart and systematically compared mobilization outcomes.
Results: First and second mobilization and collection proceeded without severe or unusual adverse effects. First-time mobilization efficiency was highly predictive of second-time mobilization. Neither mobilization efficiency nor time lag between donations affected the similarity of first- and second-time mobilization outcomes.
Conclusions: With the caveat that only donors with an unremarkable first donation were cleared for a second, our data indicate that a second donation is feasible, equally tolerable as a first donation, and efficient. Moreover, the data strongly support the notion of donor-intrinsic variables dictating mobilization response and argue against relevant damage to the stem cell compartment during mobilization with rhG-CSF.
KW  - G-CSF
KW  - Mobilization
KW  - Stem cell
KW  - Allogeneic
KW  - Volunteer donor
KW  - CD34 + cells
KW  - Second donation
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79267
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-792674
SN  - 1479-5876
N1  - The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
N1  - Open Access funding enabled and organized by Projekt DEAL.
N1  - Correspondence: h.boenig@blutspende.de; hbonig@uw.edu
VL  - 18
IS  - art. 487
SP  - 1
EP  - 6
PB  - BioMed Central
CY  - London
ER  -